Primary Literature Critique

Primary Literature Critique


The publication focuses on the appraisal of current advancements in cancer treatments applying the techniques of mitotic disruption. The authors provide a summative background into the working mechanisms of the technology by noting that the efficacy of the technique is based on the ability of the mitosis treatment into inhibiting the functioning of microtubules. Unsuccessful mitotic methods like vivo have failed in earlier periods by their ability to enhance cell fission, which is the fundamental manner in which the cancer disease spreads in a human body (Jaing, Xiaoxing, Yali, & Wei, 2006). Recent developments to overcome this issue have applied mitotic proteins in cancer treatments and therefore the study’s main question aims at reviewing the efficacy of the method. The hypothesis used in the study is that mitotic proteins provide a significant milestone in cancer treatments by their supreme efficiency when compared to drugs structured as DNA synthesizers or DNA damagers (Jaing, et al., 2006). Quantitative research is employed in the study with empirical facts being investigated in terms for an informed closure into the credibility of the formulated hypothesis.

Information used in the analysis is secondary in nature as evidenced by the reported terminologies used in the document as well as lack of primary indicators like questionnaires or the number of participants in the study. The citations also used in the discussion attribute the information to other writers and scientific investigators. Data evaluation is comparative with the introduction beginning with the identification of the manner in which the various inhibitors combat cancer, the effectuality and ineffectuality related to the methods. The categories dealt with are microtubule, kinesin motor, aurora kinase and polo-like kinase inhibitors with each bearing two, six, five and five components respectively (Jaing, et al., 2006). The study results affirmed the precision of the hypothesis by supporting the initial assertions concerning the superiority of mitotic proteins with regard to cancer treatment. The conclusion thereby accorded is that additional efforts in the study would subsequently lead to the discovery of other mitotic proteins that may offer a better form of cancer treatment.

Evaluation of Study Question

            The question is a justifiable scientific inquisition based due to the identified problem related to current cancer drugs in their inability to inhibit cell fission and consequently acting as a catalyst for the illness advancement (Jaing, et al., 2006). The authors are not the first to address the credibility of mitotic proteins in cancer treatments as the information employed is sourced from secondary materials and therefore according the necessitated information. However, they provide some sort of direction to the study by noting the lack of medical concentration in the subject. By analyzing the superiority of the technique and the route, which further cancer practitioners should apply, the authors may be viewed as imparting a level of knowledge in the subject but they are not the first to indulge into it.

Evaluation of Study Methods

            The methods were appropriate for the study as they accord a positive relationship of upholding the hypothesis and subsequently infuse credibility in the investigation. The inhibitors appraised are all kinetic proteins and therefore lack of an alternative hypothesis. Consequently, no attempt is accorded in countering the given hypothesis. This would have been achieved by the inclusion of DNA synthesizers or DNA damagers, as other cancer treatments (Jaing, et al., 2006) for an unbiased comparison to reveal the most superior of the three methods in empirical terms.

Evaluation of Study Conclusions

            The results have a high congruence with the recommended solution to cancer treatments as the technique offers credible diagrams and chemical formulas that justify the effectuality of the treatment methods. The application of empirical data is scientific but the results do not suggest any further questions, but rather a generalized direction. The information being scientific is rather persuasive but had the study contrasted the technique to existing ones, it would have had a higher impact.










Jaing, N., Xiaoxing, W., Yali, Y., & Wei, D. (2006). Advances in Mitotic Inhibitors for Cancer Treatment. Mini-Reviews in Medicinal Chemistry 6, 885-895.

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